最新藥物分子砌塊-2020/6 2020/6/15 16:29:40

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Since the proposition of the correct structure of pyridine by K?ner (1869) and Dewar (1871),this ring really became one of the most studied aromatics[1].To date, pyridines are among the most prevalent heterocyclic structural units in pharmaceutical and agrochemical targets, as well as in materials science.Pyridines also provide convenient synthetic precursors to chiral dihydro- and tetrahydropyridines,as well as piperidines, which continue to be of interest as intermediates in alkaloid synthesis,in NADH models, and as important biologically active structures[2-7].

Morpholine

A series of medicinal products containing pyridine has been firmly incorporated
                                 in medical practice.

[1] Chemical Reviews(2014), 114(21), 10829-10868.
[2] Chemical Reviews (2012), 112(5), 2642-2713.
[3] Journal of Medicinal Chemistry (2020), 10.1021/acs.jmedchem.0c00337.
[4] Journal of Medicinal Chemistry (2020), 63(2), 827-846.
[5] Journal of Medicinal Chemistry (2020), 63(4), 1724-1749.
[6] Journal of Medicinal Chemistry (2020), 63(6), 3274-3289.
[7] Journal of Medicinal Chemistry (2020), 10.1021/acs.jmedchem.9b01736.
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